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CA-MA2
General Information
DRACP ID DRACP00005
Peptide Name CA-MA2
Sequence KWKLFKKIPKFLHSAKKF
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Ceropin-Magainin hybrid peptides
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=35.1 µM | MTT assay | 3 days | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=25 µM | MTT assay | 3 days | 1 |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=20 µM | MTT assay | 3 days | 1 |
| MDA-MB-361 | Breast adenocarcinoma | Carcinoma | IC50=28 µM | MTT assay | 3 days | 1 |
Hemolytic Activity Human erythrocytes: Hemolysis 0% (100 μM)
Normal (non-cancerous) Cytotoxicity NIH-3T3 fibroblast: IC50>100 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C115H180N28O20
Absent amino acids CDEGMNQRTVY
Common amino acids K
Mass 257827
Pl 11.58
Basic residues 8
Acidic residues 0
Hydrophobic residues 8
Net charge 8
Boman Index -1907
Hydrophobicity -63.89
Aliphatic Index 70.56
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 323.53
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10675500
Title Effects of the hinge region of cecropin A(1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells
Doi 10.1016/s0005-2736(99)00210-2
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.