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1 Data

1.1 Peptide Information


- Fields Description
General information DRACP ID The field provides the unique accessing number linking to the corresponding DRACP entry.
Peptide Name Name of each peptide in DRACP.
Sequence The peptide sequence which is represented by single letter codes. L-amino acids are expressed in capital letters, and D-amino acids are expressed in small letters. X refers to modified amino acids.
Sequence Length Number of resiudes in the peptide sequence.
Uniprot ID Provide the accessing link(s) directing to external Uniprot entry(or entries).
Source The organism where the peptides or proteins were extracted or isolated.
Type Peptides are divided into Native peptide and Synthetic peptide according to their origin.
Classification Classificed by peptide type or mechanism. Including Molecularly targeted peptides, Cell-penetrating peptides, Tumor-homing peptides, Membrane-targeted mechanism, Apoptosis mechanism, Antiangiogenic mechanism...
Activity information Anticancer activity Anticancer or antitumor activity verified by experiment. Including Cell Line, Disease, Cancer Classified, Activity, Testing Assay and Time. Data from literature or patents.
Hemolytic Activity Hemolytic activity information against red blood cells (RBCs).
Normal (non-cancerous) Cytotoxicity Cytotoxicity information against normal (non-cancerous) cell line.
Target The action site of peptides against cancer cell.
Affinity Binding affinity between peptides and targets.
Mechanism The mechanism of peptides acting as anticancer agents.
Nature Biological activity classification. Except anticancer, it also includes Antibacterial, Antifungal, Antiviral...
Structure information PDB ID Provide accessing link(s) directing to the correspong PDB entry.
Predicted Structure Structure predicted by Alphafold, Show with Mol*viewer, click can download the PDB files.
Helicity α-helix percentage
Linear/Cyclic Linear or cyclic of peptides
Disulfide/Other Bond Disulfide bond (DSB) or other bond, such as sidechain-mainchain bond (SMB), N-C termini peptide bond (NCB).
N/C-terminal Modification The modifications of N/C-terminal according to the references
Other Modification Special amino acids (out of 20 common amino acids).
Chiral The L/D amino acids consist peptides.
Physicochemical Information Formula, mass, pI, Net charge and other information.
Literature Information The information of peptides come from all kinds of literature or patents, and the section provides the way to find the full text.
Link Link to other peptide databases.

1.2 Peptide Drug Information


- Fields Description
General information DRACPC ID The field provides the unique accessing number linking to the corresponding DRACPC entry.
Active Ingredients Active pharmaceutical ingredient. Substance in which the drug actually works.
Description Drug description.
Synonyms Other names of drug.
Type Drug type, mainly including small molecule drug and biotech drug.
Disease Applicable diseases.
Classification Drug Categories.
Structure information Molecular Formula, Molecular Weight, Active Sequence, Sequence Length, Modification and other structure information.
External Codes External identification code, also provides the accessing link to PubChem, DrugBank, NCI Thesaurus and GSRS.
Drug approval Including drug approval and clinical information.

2 Search help

2.1 Quick Search (Home page and Navigation bar)

Quick search allows keywords searches for sequence, peptide name and DRACP ID fields in the whole DRACP, including Peptide Library and Drug Library:

2.2 Simple Search

The Simple Search page allows you to search individual fields in Peptide Library.

  • Sequence >>> Single letter code (no space, mature peptide only) .e.g.FLPLLAGLAANFLPTIICKISYKC
  • Peptide Name >>> Name of peptides (full name or short name works) .e.g.Buforin IIb or Buforin
  • Sequence length >>> Enter the peptide sequence length number. e.g.21
  • Origin >>> Origin of peptides (full name or short name works). e.g.Skin secretions of Rana rugosa or Rana rugosa
  • UniProt ID >>> Accessing number and linking to UniProtKB/Swiss-Prot entries. e.g.P80400
  • PDB ID >>> Accessing numble of Protein Data Bank. e.g.1JMN
  • Linear/Cyclic >>> Structural properties of peptides, linear or cyclic. e.g.linear
  • Chiral>>> Stereochemical properties of amino acids. e.g.L
  • Cell Line >>> Cancer cell lines used for activity determination. e.g.K562
  • Pantent ID>>> Anticancer peptide patent query, enter the patent number. e.g.US2018/0057532A1
  • Pubmed ID>>> Anticancer peptide literature query, enter the Pubmed ID. e.g.14499271
  • Nature >>> By other Natrue searches for anticancer peptide. e.g.Antimicrobial

2.3 Advanced Search

Through any combination of keywords input panel retrieval. The relationship between each item is "and".



2.4 Drug search

The Drug search page allows you to search individual fields in Drug Library.

  • Active Sequence >>> Single letter code. e.g. AGCKNFFWKTFTSC
  • Sequence length >>> Enter the peptide sequence length number. e.g. 10
  • Active Ingredients >>> Name of active ingredient of the ACP drug. e.g. Triptorelin
  • PubChem CID >>> PubChem identification code. e.g. 25074470
  • DrugBank Accession Number >>> DrugBank identification code. e.g. DB06825
  • UNII >>> UNII identification code. e.g. 9081Y98W2V
  • CAS >>> CAS identification code. e.g. 57773-63-4

3 BLAST help

The BLAST (Basic Local Alignment Search Tool) program uses a strategy based on matching sequence fragments by employing a powerful statistical model to find the best local alignments (For more information see http://www.ebi.ac.uk/Tools/sss/ncbiblast/).

Usage Introduction

Step 1 – Sequence Input

Step 2 – Parameters

Default value is: BLOSUM62

Tip: In general, higher value BLOSUM matrices (e.g. BLOSUM90) and lower value PAM matrices (e.g. PAM30) are more stringent than low value BLOSUM or high value PAM matrices. This implies that if you want to find more distantly related homologues, you should preferentially employ a low value BLOSUM or high value PAM matrix (For more information about scoring matrices see http://en.wikipedia.org/wiki/Matrix).

DRACP is developed by Dr.Zheng's team.