This work is licensed under a Creative Commons Attribution 4.0 International License.
Aurein1.2
General Information
DRACP ID DRACP00007
Peptide Name Aurein1.2
Sequence GLFDIIKKIAESF
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Southern bell frog
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Breast tumor cell (NCI) | Breast tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Leukemia tumor cell (NCI) | Leukemia tumor | Carcinoma | LC50=10-100 µM | Not available | Not available | 1 |
| Lung tumor cell (NCI) | Lung tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Colon tumor cell (NCI) | Colon tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Brain tumor cell (NCI) | Brain tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Skin tumor cell (NCI) | Skin tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Ovary tumor cell (NCI) | Ovary tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Renal tumor cell (NCI) | Renal tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Prostate tumor cell (NCI) | Prostate tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Anticancer activity is due to penetration and disruption of the membranes of the cancer cells
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C71H113N15O19
Absent amino acids CHMNPQRTVWY
Common amino acids I
Mass 169500
Pl 6.49
Basic residues 2
Acidic residues 2
Hydrophobic residues 7
Net charge 0
Boman Index -164
Hydrophobicity 66.92
Aliphatic Index 127.69
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10951191
Title The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2
Doi 10.1046/j.1432-1327.2000.01536.x
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_779
This work is licensed under a Creative Commons Attribution 4.0 International License.