This work is licensed under a Creative Commons Attribution 4.0 International License.
Aurein2.5
General Information
DRACP ID DRACP00011
Peptide Name Aurein2.5
Sequence GLFDIVKKVVGAFGSL
Sequence Length 16
PubChem CID Not available
Origin Southern bell frog
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Breast tumor cell (NCI) | Breast tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Leukemia tumor cell (NCI) | Leukemia tumor | Carcinoma | LC50=10-100 µM | Not available | Not available | 1 |
| Lung tumor cell (NCI) | Lung tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Colon tumor cell (NCI) | Colon tumor | Carcinoma | LC50=10-100 µM | Not available | Not available | 1 |
| Brain tumor cell (NCI) | Brain tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Skin tumor cell (NCI) | Skin tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Ovary tumor cell (NCI) | Ovary tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Renal tumor cell (NCI) | Renal tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
| Prostate tumor cell (NCI) | Prostate tumor | Carcinoma | LC50=10 µM | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Anticancer activity is due to penetration and disruption of the membranes of the cancer cells
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C79H128N18O20
Absent amino acids CEHMNPQRTWY
Common amino acids GV
Mass 191774
Pl 9.54
Basic residues 2
Acidic residues 1
Hydrophobic residues 9
Net charge 1
Boman Index 1425
Hydrophobicity 117.5
Aliphatic Index 133.75
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10951191
Title The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2
Doi 10.1046/j.1432-1327.2000.01536.x
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.