This work is licensed under a Creative Commons Attribution 4.0 International License.
CRAMP
General Information
DRACP ID DRACP00012
Peptide Name CRAMP
Sequence ISRLAGLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPE
Sequence Length 38
UniProt ID Not available
PubChem CID Not available
Origin Mus musculus
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL14 positive; Chronic myeloid leukemia | Leukemia | IC50=28 µM | MTT assay | 3 days | 1 |
| Jurkat E6.1 | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=16 µM | MTT assay | 3 days | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=22 µM | MTT assay | 3 days | 1 |
Hemolytic Activity Human erythrocytes: 2% Hemolysis=100 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C197H338N56O50
Absent amino acids CDHMTWY
Common amino acids K
Mass 495135
Pl 11.25
Basic residues 10
Acidic residues 3
Hydrophobic residues 13
Net charge 7
Boman Index -6054
Hydrophobicity -58.16
Aliphatic Index 102.63
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10973820
Title CRAMP analogues having potent antibiotic activity against bacterial, fungal, and tumor cells without hemolytic activity
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.