This work is licensed under a Creative Commons Attribution 4.0 International License.
Hepcidin-25
General Information
DRACP ID DRACP00013
Peptide Name Hepcidin-25
Sequence DTHFPICIFCCGCCHRSKCGMCCKT
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Homo sapiens; Pan troglodytes; Pongo pygmaeus; Gorilla gorilla; Nomascus concolor; Hylobates lar
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL15 positive; Chronic myeloid leukemia | Leukemia | 26% Killing=30 µM | Trypan blue assay | 15 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys7<--->Cys23; Cys10<--->Cys13; Cys11<--->Cys19; Cys14<--->Cys22
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C113H178N34O31S9
Absent amino acids AELNQVWY
Common amino acids C
Mass 322570
Pl 7.98
Basic residues 5
Acidic residues 1
Hydrophobic residues 4
Net charge 4
Boman Index -2233
Hydrophobicity 38.8
Aliphatic Index 31.2
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 500
Absorbance 280nm 20.83
Polar residues 13
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11113131
Title Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Year 2001
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.