This work is licensed under a Creative Commons Attribution 4.0 International License.
Hepcidin-20
General Information
DRACP ID DRACP00014
Peptide Name Hepcidin-20
Sequence ICIFCCGCCHRSKCGMCCKT
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Homo sapiens; Pan troglodytes; Pongo pygmaeus; Gorilla gorilla; Nomascus concolor; Hylobates lar
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL16 positive; Chronic myeloid leukemia | Leukemia | 12% Killing=30 µM | Trypan blue assay | 15 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys2<--->Cys18; Cys5<--->Cys8; Cys6<--->Cys14; Cys9<--->Cys17
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C85H143N27O23S9
Absent amino acids ADELNPQVWY
Common amino acids C
Mass 253889
Pl 8.21
Basic residues 4
Acidic residues 0
Hydrophobic residues 3
Net charge 4
Boman Index -936
Hydrophobicity 79.5
Aliphatic Index 39
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: >10 hour
Extinction Coefficient cystines 500
Absorbance 280nm 26.32
Polar residues 12
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11113131
Title Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Year 2001
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.