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maximin 1
General Information
DRACP ID DRACP00015
Peptide Name maximin 1
Sequence GIGTKILGGVKTALKGALKELASTYAN
Sequence Length 27
UniProt ID Q58T87 P83080 C3RTK8
PubChem CID Not available
Origin Bombina maxima
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| C8166 | Adult T acute lymphoblastic leukemia | Leukemia | IC50=15.3 µg/ml | MTT assay | 48 h | 1 |
| Molt-4 | Adult T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=24.3 µg/ml | MTT assay | 48 h | 1 |
| BIU-87 | Bladder carcinoma | Carcinoma | IC50=20.5 µg/ml | MTT assay | 48 h | 1 |
| T24 | Bladder carcinoma | Carcinoma | IC50=35.4 µg/ml | MTT assay | 48 h | 1 |
Hemolytic Activity Had little hemolytic activity to red blood cells even with the concentration of the peptides up to 50 μg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C120H208N32O36
Absent amino acids CDFHMPQRW
Common amino acids G
Mass 313913
Pl 10.48
Basic residues 4
Acidic residues 1
Hydrophobic residues 11
Net charge 3
Boman Index -140
Hydrophobicity 25.19
Aliphatic Index 112.22
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 57.31
Polar residues 11
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11835991
Title Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima
Doi 10.1016/s0196-9781(01)00641-6
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_832
This work is licensed under a Creative Commons Attribution 4.0 International License.