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maximin 4
General Information
DRACP ID DRACP00017
Peptide Name maximin 4
Sequence GIGGVLLSAGKAALKGLAKVLAEKYAN
Sequence Length 27
UniProt ID P83083 Q58T79 Q58T52 Q58T42 Q58T44 Q58T62 Q58T77 B5L113 C3RTJ1 B5L130 C3RSS2 C3RSS3 C3RSY5 C3RSY6 C3RSY7 C3RSY8 C3RTJ5
PubChem CID Not available
Origin Bombina maxima
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| C8166 | Adult T acute lymphoblastic leukemia | Leukemia | IC50=24.2 µg/ml | MTT assay | 48 h | 1 |
| Molt-4 | Adult T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=35.4 µg/ml | MTT assay | 48 h | 1 |
| BIU-87 | Bladder carcinoma | Carcinoma | IC50>50 µg/ml | MTT assay | 48 h | 1 |
| T24 | Bladder carcinoma | Carcinoma | IC50>50 µg/ml | MTT assay | 48 h | 1 |
Hemolytic Activity Had little hemolytic activity to red blood cells even with the concentration of the peptides up to 50 μg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C119H206N32O33
Absent amino acids CDFHMPQRTW
Common amino acids A
Mass 307712
Pl 10.48
Basic residues 4
Acidic residues 1
Hydrophobic residues 14
Net charge 3
Boman Index 1397
Hydrophobicity 59.26
Aliphatic Index 130.37
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 57.31
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11835991
Title Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima
Doi 10.1016/s0196-9781(01)00641-6
Year 2002
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_841
This work is licensed under a Creative Commons Attribution 4.0 International License.