This work is licensed under a Creative Commons Attribution 4.0 International License.
novispirin G-10
General Information
DRACP ID DRACP00019
Peptide Name novispirin G-10
Sequence KNLRRIIRKGIHIIKKYG
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| ME-180 | Human papillomavirus-related cervical squamous cell carcinoma; Squamous cell carcinoma of the cervix uteri | Carcinoma | 33.2% Cytotoxicity=200 µg/ml | MTT assay | 20h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | 33.2% Cytotoxicity=200 µg/ml | MTT assay | 20h | 1 |
Hemolytic Activity Human erythrocytes: 3% Hemolysis=80 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C101H180N34O21
Absent amino acids ACDEFMPQSTVW
Common amino acids I
Mass 251017
Pl 12.28
Basic residues 8
Acidic residues 0
Hydrophobic residues 6
Net charge 8
Boman Index -4700
Hydrophobicity -64.44
Aliphatic Index 130
Half Life
Mammalian: 1.9 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 87.65
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 11932493
Title Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides
Year 2002
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_696
This work is licensed under a Creative Commons Attribution 4.0 International License.