Peptide Libraray

HNP-1

General Information

DRACP ID DRACP00022

Peptide Name HNP-1

Sequence ACYCRIPACIAGERRYGTCIYQGRLWAFCC

Sequence Length 30

UniProt ID P59665 G3QPD5

PubChem CID Not available

Origin Human alpha-defensins

Type Native peptide

Classification

Active ACP Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
RCCs (A-498, Caki-2, 786-0, 769-P, ACHN, LE 9211-RCC, TW33, N43)	Renal Cell Carcinoma	Carcinoma	At higher concentrations than 25 μg/ml, HNPs-1, -2, and -3 exerted cytotoxic effects on all tested RCC lines in an in vitro serum-free culture system (at lower concentrations they stimulated cell grow	WST-1 assay	40 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID 2KHT 3HJ2 3LVX 4LBB 3HJD

Predicted Structure DRACP00022

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys2<--->Cys30; Cys4<--->Cys19; Cys9<--->Cys29

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C150H228N44O38S6

Absent amino acids DHKMNSV

Common amino acids C

Mass 396557

Pl 8.37

Basic residues 4

Acidic residues 1

Hydrophobic residues 10

Net charge 3

Boman Index -3229

Hydrophobicity 30

Aliphatic Index 65.33

Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 10345

Absorbance 280nm 356.72

Polar residues 13

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 11943716

Title Human alpha-defensins HNPs-1, -2, and -3 in renal cell carcinoma: influences on tumor cell proliferation

Doi 10.1016/s0002-9440(10)62558-8

Year 2002

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

CancerPPD ID 4430