Peptide Libraray

HNP-2

General Information

DRACP ID DRACP00023

Peptide Name HNP-2

Sequence CYCRIPACIAGERRYGTCIYQGRLWAFCC

Sequence Length 29

UniProt ID P59666 P59665 Q6EZE9 G3QPD5

PubChem CID Not available

Origin Human alpha-defensins

Type Native peptide

Classification

Active ACP Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
RCCs (A-498, Caki-2, 786-0, 769-P, ACHN, LE 9211-RCC, TW33, N43)	Renal Cell Carcinoma	Carcinoma	At higher concentrations than 25 μg/ml, HNPs-1, -2, and -3 exerted cytotoxic effects on all tested RCC lines in an in vitro serum-free culture system (at lower concentrations they stimulated cell grow	WST-1 assay	40 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure DRACP00023

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys1<--->Cys29; Cys9<--->Cys18; Cys8<--->Cys28

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C147H223N43O37S6

Absent amino acids DHKMNSV

Common amino acids C

Mass 387665

Pl 8.37

Basic residues 4

Acidic residues 1

Hydrophobic residues 9

Net charge 3

Boman Index -3410

Hydrophobicity 24.83

Aliphatic Index 64.14

Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 10345

Absorbance 280nm 369.46

Polar residues 13

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 11943716

Title Human alpha-defensins HNPs-1, -2, and -3 in renal cell carcinoma: influences on tumor cell proliferation

Doi 10.1016/s0002-9440(10)62558-8

Year 2002

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

CancerPPD ID 4431