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C-5
General Information
DRACP ID DRACP00041
Peptide Name C-5
Sequence KWKLFKKIPHLAKKF
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Ceropin A
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-361 | Breast adenocarcinoma | Carcinoma | IC50=100 µM | MTT assay | 3 days | 1 |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=81 µM | MTT assay | 3 days | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=67 µM | MTT assay | 3 days | 1 |
Hemolytic Activity Human erythrocytes: hemolysis: 0%=100 µM; hemolysis: 0%=50 µM; hemolysis: 0%=25.0 µM; hemolysis: 0%=12.5 µM; hemolysis: 0%=6.25 µM; hemolysis: 0%=3.125 µM; hemolysis: 0%=1.56 µM; hemolysis: 0%=0.78 µM
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=100.0< µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C97H154N24O16
Absent amino acids CDEGMNQRSTVY
Common amino acids K
Mass 216234
Pl 11.5
Basic residues 7
Acidic residues 0
Hydrophobic residues 7
Net charge 7
Boman Index -1310
Hydrophobicity -64
Aliphatic Index 84.67
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 392.86
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12005420
Title Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs
Doi 10.1034/j.1399-3011.2001.00934.x
Year 2001
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.