Peptide Libraray

Alloferon 1

General Information

DRACP ID DRACP00052

Peptide Name Alloferon 1

Sequence HGVSGHGQHGVHG

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin the blow fly Calliphora vicina (Diptera)

Type Native peptide

Classification

Active ACP Immune system stimulating peptides

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
K562	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia	Leukemia	lower doses of cancer cells could be eliminated after administration of 25 μg of alloferon	Not available	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism (i) stimulates natural cytotoxicity of human peripheral blood lymphocytes, (ii) induces IFN synthesis in mouse and human models, and (iii) enhances antiviral and antitumor resistance in mice.

Nature Anticancer; Antitumor; Antiviral

Structure Information

PDB ID Not available

Predicted Structure DRACP00052

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C52H76N22O16

Absent amino acids ACDEFIKLMNPRTWY

Common amino acids G

Mass 147955

Pl 7.88

Basic residues 4

Acidic residues 0

Hydrophobic residues 2

Net charge 4

Boman Index -1480

Hydrophobicity -82.31

Aliphatic Index 44.62

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 6

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 12235362

Title Antiviral and antitumor peptides from insects

Doi 10.1073/pnas.192301899

Year 2002

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available