This work is licensed under a Creative Commons Attribution 4.0 International License.
LFB 14-31 (L1)
General Information
DRACP ID DRACP00053
Peptide Name LFB 14-31 (L1)
Sequence PEWFKCRRWQWRMKKLGA
Sequence Length 18
UniProt ID P24627
PubChem CID Not available
Origin Bovine Lactoferrin
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Meth A | Mouse fibrosarcoma | Sarcoma | IC50>404 µM | MTT assay | 4 h | 1 |
| MT-1 | Human mammary carcinoma | Carcinoma | IC50>404 µM | MTT assay | 4 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50>404 µM | MTT assay | 4 h | 1 |
Hemolytic Activity Human red blood cells: EC50>404 µM
Normal (non-cancerous) Cytotoxicity Fibroblas: IC50>404 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C112H168N34O22S2
Absent amino acids DHINSTVY
Common amino acids KRW
Mass 271030
Pl 11.65
Basic residues 6
Acidic residues 1
Hydrophobic residues 6
Net charge 5
Boman Index -5249
Hydrophobicity -133.89
Aliphatic Index 27.22
Half Life
Mammalian: 3.5 hour
Yeast: 10 min
E.coli: >10 hour
Extinction Coefficient cystines 16500
Absorbance 280nm 970.59
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12366526
Title Enhanced antitumor activity and selectivity of lactoferrin-derived peptides
Doi 10.1034/j.1399-3011.2002.21008.x
Year 2002
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.