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L4
General Information
DRACP ID DRACP00056
Peptide Name L4
Sequence PAWFKARRWAWRMLKKAA
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Meth A | Mouse fibrosarcoma | Sarcoma | IC50=31 µM | MTT assay | 4 h | 1 |
| MT-1 | Human mammary carcinoma | Carcinoma | IC50=16 µM | MTT assay | 4 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=57 µM | MTT assay | 4 h | 1 |
Hemolytic Activity Human red blood cells: EC50>440 µM
Normal (non-cancerous) Cytotoxicity Fibroblas: IC50=299 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C109H165N33O19S
Absent amino acids CDEGHINQSTVY
Common amino acids A
Mass 257719
Pl 12.82
Basic residues 6
Acidic residues 0
Hydrophobic residues 10
Net charge 6
Boman Index -3512
Hydrophobicity -66.67
Aliphatic Index 49.44
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 16500
Absorbance 280nm 970.59
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12366526
Title Enhanced antitumor activity and selectivity of lactoferrin-derived peptides
Doi 10.1034/j.1399-3011.2002.21008.x
Year 2002
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.