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L13
General Information
DRACP ID DRACP00065
Peptide Name L13
Sequence PAWRKAFRKAWRMLKKAA
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Meth A | Mouse fibrosarcoma | Sarcoma | IC50=14 µM | MTT assay | 4 h | 1 |
| MT-1 | Human mammary carcinoma | Carcinoma | IC50=12 µM | MTT assay | 4 h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=29 µM | MTT assay | 4 h | 1 |
Hemolytic Activity Human red blood cells: EC50>451 µM
Normal (non-cancerous) Cytotoxicity Fibroblas: IC50=59 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C104H167N33O19S
Absent amino acids CDEGHINQSTVY
Common amino acids A
Mass 251915
Pl 12.83
Basic residues 7
Acidic residues 0
Hydrophobic residues 9
Net charge 7
Boman Index -4300
Hydrophobicity -83.33
Aliphatic Index 49.44
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 11000
Absorbance 280nm 647.06
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12366526
Title Enhanced antitumor activity and selectivity of lactoferrin-derived peptides
Doi 10.1034/j.1399-3011.2002.21008.x
Year 2002
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.