This work is licensed under a Creative Commons Attribution 4.0 International License.
MG2d
General Information
DRACP ID DRACP00068
Peptide Name MG2d
Sequence GIGKFLHSAKKWGKAFVGQIMNC
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 30-40% viablity=100 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C116H182N32O27S2
Absent amino acids DEPRTY
Common amino acids GK
Mass 291365
Pl 10.8
Basic residues 5
Acidic residues 0
Hydrophobic residues 9
Net charge 5
Boman Index -434
Hydrophobicity 6.52
Aliphatic Index 72.17
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 5500
Absorbance 280nm 250
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12417587
Title Translocation of analogues of the antimicrobial peptides magainin and buforin across human cell membranes
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.