This work is licensed under a Creative Commons Attribution 4.0 International License.
Tat (47-57)
General Information
DRACP ID DRACP00070
Peptide Name Tat (47-57)
Sequence YGRKKRRQRRR
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Transducing peptide Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 55-65% viablity=100 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C64H118N32O14
Absent amino acids ACDEFHILMNPSTVW
Common amino acids R
Mass 173837
Pl 12.81
Basic residues 8
Acidic residues 0
Hydrophobic residues 0
Net charge 8
Boman Index -10536
Hydrophobicity -363.64
Aliphatic Index 0
Half Life
Mammalian: 7.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 149
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12417587
Title Translocation of analogues of the antimicrobial peptides magainin and buforin across human cell membranes
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.