This work is licensed under a Creative Commons Attribution 4.0 International License.
Citropin 1.1
General Information
DRACP ID DRACP00077
Peptide Name Citropin 1.1
Sequence GLFDVIKKVASVIGGL
Sequence Length 16
UniProt ID P81835
PubChem CID Not available
Origin Amphibian skin secretions
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Leukemia group (NCI) | Leukemia | Leukemia | IC50=10 μM | Not available | Not available | 1 |
| Lung cancer group (NCI) | Lung Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| Colon cancer group (NCI) | Colon Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| CNS cancer group (NCI) | CNS Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| Melanoma cancer group (NCI) | Melanoma cancer group (NCI) | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| Ovarian cancer group (NCI) | Ovarian Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| Renal cancer group (NCI) | Renal Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| Prostate cancer group (NCI) | Prostate Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| Breast cancer group (NCI) | Breast Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C76H130N18O20
Absent amino acids CEHMNPQRTWY
Common amino acids GV
Mass 188373
Pl 9.54
Basic residues 2
Acidic residues 1
Hydrophobic residues 9
Net charge 1
Boman Index 1619
Hydrophobicity 128.13
Aliphatic Index 158.13
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12631273
Title nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications
Doi 10.1046/j.1432-1033.2003.03462.x
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.