This work is licensed under a Creative Commons Attribution 4.0 International License.
Citropin 3
General Information
DRACP ID DRACP00079
Peptide Name Citropin 3
Sequence GLFAVIKKVASVIGGL
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Amphibian skin secretions
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Leukemia group (NCI) | Leukemia | Leukemia | IC50>1 μM | Not available | Not available | 1 |
| Lung cancer group (NCI) | Lung Carcinoma | Carcinoma | IC50=1 μM | Not available | Not available | 1 |
| Colon cancer group (NCI) | Colon Carcinoma | Carcinoma | IC50=1 μM | Not available | Not available | 1 |
| CNS cancer group (NCI) | CNS Carcinoma | Carcinoma | IC50=1 μM | Not available | Not available | 1 |
| Melanoma cancer group (NCI) | Melanoma cancer group (NCI) | Carcinoma | IC50=1 μM | Not available | Not available | 1 |
| Ovarian cancer group (NCI) | Ovarian Carcinoma | Carcinoma | IC50=1 μM | Not available | Not available | 1 |
| Renal cancer group (NCI) | Renal Carcinoma | Carcinoma | IC50=1 μM | Not available | Not available | 1 |
| Prostate cancer group (NCI) | Prostate Carcinoma | Carcinoma | IC50=1 μM | Not available | Not available | 1 |
| Breast cancer group (NCI) | Breast Carcinoma | Carcinoma | IC50=1 μM | Not available | Not available | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=28 ± 1 μM(pH=7.4); IC50=25 ± 2 μM(pH=5.5) | MTT assay | 2 h | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity CHO: IC50=19 ± 2 μM(pH=7.4); IC50=21 ± 1 μM(pH=5.5)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C75H130N18O18
Absent amino acids CDEHMNPQRTWY
Common amino acids GV
Mass 183972
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 10
Net charge 2
Boman Index 2672
Hydrophobicity 161.25
Aliphatic Index 164.38
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12631273
Title nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications
Doi 10.1046/j.1432-1033.2003.03462.x
Year 2003
Literature 2
Pubmed ID 19464332
Title Constructing bioactive peptides with pH-dependent activities
Doi 10.1016/j.peptides.2009.05.009
Year 2009
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.