Citropin 11

General Information


DRACP ID  DRACP00082

Peptide Name   Citropin 11

Sequence  GLFDVIKKVASVIKGL

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Amphibian skin secretions

Type  Synthetic peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
Leukemia group (NCI) Leukemia Leukemia IC50=10 μM Not available Not available 1
Lung cancer group (NCI) Lung Carcinoma Carcinoma IC50=10 μM Not available Not available 1
Colon cancer group (NCI) Colon Carcinoma Carcinoma IC50=10 μM Not available Not available 1
CNS cancer group (NCI) CNS Carcinoma Carcinoma IC50=10 μM Not available Not available 1
Melanoma cancer group (NCI) Melanoma cancer group (NCI) Carcinoma IC50=10 μM Not available Not available 1
Ovarian cancer group (NCI) Ovarian Carcinoma Carcinoma IC50=10 μM Not available Not available 1
Renal cancer group (NCI) Renal Carcinoma Carcinoma IC50=10 μM Not available Not available 1
Prostate cancer group (NCI) Prostate Carcinoma Carcinoma IC50=10 μM Not available Not available 1
Breast cancer group (NCI) Breast Carcinoma Carcinoma IC50=10 μM Not available Not available 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00082

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C80H139N19O20

Absent amino acids  CEHMNPQRTWY

Common amino acids  KV

Mass  195485

Pl  10.51

Basic residues  3

Acidic residues  1

Hydrophobic residues  9

Net charge  2

Boman Index  970

Hydrophobicity  106.25

Aliphatic Index  158.13

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 12631273

Title  nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications

Doi 10.1046/j.1432-1033.2003.03462.x

Year  2003

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.