This work is licensed under a Creative Commons Attribution 4.0 International License.
Citropin 22
General Information
DRACP ID DRACP00090
Peptide Name Citropin 22
Sequence GLFKVIKKVASVIGGL
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Amphibian skin secretions
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Leukemia group (NCI) | Leukemia | Leukemia | IC50>10 μM | Not available | Not available | 1 |
| Lung cancer group (NCI) | Lung Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| Colon cancer group (NCI) | Colon Carcinoma | Carcinoma | IC50>10 μM | Not available | Not available | 1 |
| CNS cancer group (NCI) | CNS Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| Melanoma cancer group (NCI) | Melanoma cancer group (NCI) | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| Ovarian cancer group (NCI) | Ovarian Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| Renal cancer group (NCI) | Renal Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| Prostate cancer group (NCI) | Prostate Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
| Breast cancer group (NCI) | Breast Carcinoma | Carcinoma | IC50=10 μM | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C78H137N19O18
Absent amino acids CDEHMNPQRTWY
Common amino acids GKV
Mass 189681
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 9
Net charge 3
Boman Index 1936
Hydrophobicity 125.63
Aliphatic Index 158.13
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12631273
Title nNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications
Doi 10.1046/j.1432-1033.2003.03462.x
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.