This work is licensed under a Creative Commons Attribution 4.0 International License.
l3,4,8,10K5L7
General Information
DRACP ID DRACP00093
Peptide Name l3,4,8,10K5L7
Sequence KLllKLKlKlLK
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Diastereomeric peptide
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| B16-F10 | Mouse melanoma | Carcinoma | LC50=100 µM | XTT assay | 24h | 1 |
| D122 | Malignant tumors of the mouse pulmonary system | Carcinoma | LC50>50 µM | XTT assay | 24h | 1 |
Hemolytic Activity Human erythrocyte: Hemolysis% at 50 μm peptide LC50=0 µM
Normal (non-cancerous) Cytotoxicity NIH-3T3: LC50>100 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification l=D-Leucine; k=D-Lysine
Chiral Mix
Physicochemical Information
Formula C48H87N13O5
Absent amino acids ACDEFGHIMNPQRSTVWY
Common amino acids K
Mass 112269
Pl 11.4
Basic residues 5
Acidic residues 0
Hydrophobic residues 3
Net charge 5
Boman Index -1299
Hydrophobicity -67.5
Aliphatic Index 97.5
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12646578
Title Designed antimicrobial and antitumor peptides with high selectivity
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.