This work is licensed under a Creative Commons Attribution 4.0 International License.
MRP
General Information
DRACP ID DRACP00095
Peptide Name MRP
Sequence AIGSILGALAKGLPTLISWIKNR
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Rana tagoi
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| EL4 T-lymphoma | T-cell lymphoma | Lymphoma | LC50=14 μM | Trypan blue assay | 1 h | 1 |
Hemolytic Activity Human erythrocytes: HC50=8 μM
Normal (non-cancerous) Cytotoxicity L929: LC50=20 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C111H190N30O28
Absent amino acids CDEFHMQVY
Common amino acids IL
Mass 278553
Pl 11.82
Basic residues 3
Acidic residues 0
Hydrophobic residues 12
Net charge 3
Boman Index 791
Hydrophobicity 73.04
Aliphatic Index 148.7
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 250
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 12804591
Title A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties
Doi 10.1016/s0006-291x(03)00999-9
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.