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Magainin A
General Information
DRACP ID DRACP00096
Peptide Name Magainin A
Sequence AIGKFLHSAKKFGKAFVGEIMNS
Sequence Length 23
PubChem CID Not available
Origin African clawed frog Xenopus laevis skin
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H82 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=7.28 µM | MTT assay | 24 h | 1 |
| NCI-H526 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=11.7 µM | MTT assay | 24 h | 1 |
| NCI-H678 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=6.23 µM | MTT assay | 24 h | 1 |
| NCI-H735 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=10.4 µM | MTT assay | 24 h | 1 |
| NCI-H841 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=9.7 µM | MTT assay | 24 h | 1 |
| NCI-H889 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=6.56 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Detectable but low hemolytic activity
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Beta-alanine
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C115H182N30O29S
Absent amino acids CDPQRTWY
Common amino acids K
Mass 287355
Pl 10.8
Basic residues 5
Acidic residues 1
Hydrophobic residues 10
Net charge 4
Boman Index -877
Hydrophobicity 17.83
Aliphatic Index 76.52
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 1319823
Title Antitumor activity of magainin analogues against human lung cancer cell lines
Doi Not available
Year 1992
Literature 2
Pubmed ID 2285300
Title Magainin analogs effective against pathogenic protozoa
Year 1990
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.