This work is licensed under a Creative Commons Attribution 4.0 International License.
Magainin G
General Information
DRACP ID DRACP00097
Peptide Name Magainin G
Sequence GIGKFLHSAKKFAKAFVAEIMNS
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin African clawed frog Xenopus laevis skin
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H82 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=12.5 µM | MTT assay | 24 h | 1 |
| NCI-H526 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=10.5 µM | MTT assay | 24 h | 1 |
| NCI-H678 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=4.44 µM | MTT assay | 24 h | 1 |
| NCI-H735 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=7.23 µM | MTT assay | 24 h | 1 |
| NCI-H841 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=11.7 µM | MTT assay | 24 h | 1 |
| NCI-H889 | Lung small cell carcinoma; Small cell lung cancer | Carcinoma | IC50=6.57 µM | MTT assay | 24 h | 1 |
Hemolytic Activity Magainin G showed <1% hemolytic activity at 200 μg /ml (65.7μM)
Normal (non-cancerous) Cytotoxicity Magainin G did not exhibit cytotoxic effects on normal human peripheral blood lymphocytes at concentrations of up to 100-200 μg/ml (32.9-65.7 μM)
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Beta-alanine
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C116H184N30O29S
Absent amino acids CDPQRTWY
Common amino acids AK
Mass 288758
Pl 10.8
Basic residues 5
Acidic residues 1
Hydrophobic residues 11
Net charge 4
Boman Index -790
Hydrophobicity 27.39
Aliphatic Index 80.87
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 1319823
Title Antitumor activity of magainin analogues against human lung cancer cell lines
Doi Not available
Year 1992
Literature 2
Pubmed ID 2285300
Title Magainin analogs effective against pathogenic protozoa
Year 1990
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.