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GGN6 (gaegurin 6)
General Information
DRACP ID DRACP00098
Peptide Name GGN6 (gaegurin 6)
Sequence FLPLLAGLAANFLPTIICKISYKC
Sequence Length 24
UniProt ID P80400
PubChem CID Not available
Origin Skin secretions of Rana rugosa
Type Native peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=6.49 ± 1.39 µg/ml | MTT assay | 96 h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=5.75±1.17 µg/ml | MTT assay | 96 h | 1 |
| Hep 3B | Childhood hepatocellular carcinoma; Pediatric hepatocellular carcinoma | Carcinoma | IC50=4.91±0.80 µg/ml | MTT assay | 96 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=4.88±0.53 µg/ml | MTT assay | 96 h | 1 |
Hemolytic Activity Human RBCs: less than 6% hemolysis at 100 μg/ml
Normal (non-cancerous) Cytotoxicity HEK293: IC50=5.62±1.50 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys18<--->Cys24
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C125H201N27O29S2
Absent amino acids DEHMQRVW
Common amino acids L
Mass 302071
Pl 8.79
Basic residues 2
Acidic residues 0
Hydrophobic residues 13
Net charge 2
Boman Index 3040
Hydrophobicity 128.33
Aliphatic Index 142.5
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1615
Absorbance 280nm 70.22
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 14499271
Title In vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines
Doi 10.1016/s0196-9781(03)00194-3
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.