Peptide Libraray

PTP1

General Information

DRACP ID DRACP00099

Peptide Name PTP1

Sequence LLAGLAANFLPTIICKISYKC

Sequence Length 21

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP Induce apoptosis

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	Carcinoma	IC50>100 µg/ml	MTT assay	96 h	1
PC-3	Prostate carcinoma	Carcinoma	IC50>100 µg/ml	MTT assay	96 h	1
Hep 3B	Childhood hepatocellular carcinoma; Pediatric hepatocellular carcinoma	Carcinoma	IC50>100 µg/ml	MTT assay	96 h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	IC50>100 µg/ml	MTT assay	96 h	1

Hemolytic Activity Human RBCs: less than 6% hemolysis at 100 μg/ml

Normal (non-cancerous) Cytotoxicity HEK293: IC50>100 µg/ml

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure DRACP00099

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys15<--->Cys21

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C105H174N24O26S2

Absent amino acids DEHMQRVW

Common amino acids L

Mass 260975

Pl 8.79

Basic residues 2

Acidic residues 0

Hydrophobic residues 11

Net charge 2

Boman Index 2250

Hydrophobicity 122.86

Aliphatic Index 144.29

Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 1615

Absorbance 280nm 80.75

Polar residues 7

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 14499271

Title In vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines

Doi 10.1016/s0196-9781(03)00194-3

Year 2003

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available