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PTP4
General Information
DRACP ID DRACP00101
Peptide Name PTP4
Sequence FLKLLKKLAAKFLPTIICKISYKC
Sequence Length 24
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=13.71 ± 2.12 µg/ml | MTT assay | 96 h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=18.63 ± 0.99 µg/ml | MTT assay | 96 h | 1 |
| Hep 3B | Childhood hepatocellular carcinoma; Pediatric hepatocellular carcinoma | Carcinoma | IC50=18.18 ± 3.31 µg/ml | MTT assay | 96 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=18.10 ± 2.13 µg/ml | MTT assay | 96 h | 1 |
Hemolytic Activity Human RBCs: 45.17% hemolysis at 100 μg/ml
Normal (non-cancerous) Cytotoxicity HEK293: IC50=26.15 ± 6.23 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C135H228N30O28S2
Absent amino acids DEGHMNQRVW
Common amino acids K
Mass 319405
Pl 10.59
Basic residues 6
Acidic residues 0
Hydrophobic residues 12
Net charge 6
Boman Index 1209
Hydrophobicity 78.75
Aliphatic Index 138.33
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 1615
Absorbance 280nm 70.22
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 14499271
Title In vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines
Doi 10.1016/s0196-9781(03)00194-3
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.