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PTP7
General Information
DRACP ID DRACP00104
Peptide Name PTP7
Sequence FLGALFKALSKLL
Sequence Length 13
UniProt ID P80399
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=8.01 ± 1.32 µg/ml | MTT assay | 96 h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=5.01±0.42 µg/ml | MTT assay | 96 h | 1 |
| Hep 3B | Childhood hepatocellular carcinoma; Pediatric hepatocellular carcinoma | Carcinoma | IC50=5.40 ± 0.91 µg/ml | MTT assay | 96 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=5.25±0.63 µg/ml | MTT assay | 96 h | 1 |
| PANC-1 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50=11 μM | MTT assay | 2 h | 2 |
Hemolytic Activity Human RBCs: less than 6% hemolysis at 100 μg/ml
Normal (non-cancerous) Cytotoxicity HEK293: IC50=6.71 ± 0.47 µg/ml; MCF-10A: IC50=8 μM
Target Not available
Affinity Not available
Mechanism Induce cell death via apoptosis
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C71H117N15O15
Absent amino acids CDEHIMNPQRTVWY
Common amino acids L
Mass 163504
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 9
Net charge 2
Boman Index 2062
Hydrophobicity 147.69
Aliphatic Index 165.38
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 14499271
Title In vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines
Doi 10.1016/s0196-9781(03)00194-3
Year 2003
Literature 2
Pubmed ID 22526264
Title Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
CancerPPD ID 1007
CancerPPD ID 1015
CancerPPD ID 1023
CancerPPD ID 1031
CancerPPD ID 1039
DBAASP ID DBAASPS_2323
This work is licensed under a Creative Commons Attribution 4.0 International License.