This work is licensed under a Creative Commons Attribution 4.0 International License.
Gymnin
General Information
DRACP ID DRACP00106
Peptide Name Gymnin
Sequence KTCENLADDY
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Gymnocladus chinensis
Type Native peptide
Classification
Active ACP Affect cell cycle
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | 37±4% Reduction in viability=50.0 µM | MTT assay | 72h | 1 |
| M1 | Mouse myeloid leukemia | Leukemia | 49±3% Reduction in viability=50.0 µM | MTT assay | 72h | 1 |
| L1210 | Mouse leukemia | Leukemia | 40±3% Reduction in viability=50.0 µM | MTT assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antifungal; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C48H74N12O20S
Absent amino acids FGHIMPQRSVW
Common amino acids D
Mass 133197
Pl 3.88
Basic residues 1
Acidic residues 3
Hydrophobic residues 2
Net charge -2
Boman Index -3114
Hydrophobicity -118
Aliphatic Index 49
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 1490
Absorbance 280nm 165.56
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 14499273
Title Gymnin, a potent defensin-like antifungal peptide from the Yunnan bean (Gymnocladus chinensis Baill)
Doi 10.1016/s0196-9781(03)00192-x
Year 2003
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.