Peptide Libraray

p773–782

General Information

DRACP ID DRACP00108

Peptide Name p773–782

Sequence VMAGVGSPYV

Sequence Length 10

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP Immune system stimulating peptides

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
N202.A2	Spontaneous tumor in A2×neu mice	--	Animals immunized three times with DC pulsed with p369–377 or p773–782 peptide showed ~25–30% tumor growth inhibition, while two immunizations induced ~12–15% tumor growth inhibition and one injection	Not available	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism The low-avidity T cell repertoire for a self tumor antigen is functional, can be activated and expanded with the help of costimulation

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure DRACP00108

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C44H70N10O13S

Absent amino acids CDEFHIKLNQRTW

Common amino acids V

Mass 113987

Pl 6.09

Basic residues 0

Acidic residues 0

Hydrophobic residues 4

Net charge 0

Boman Index 1462

Hydrophobicity 118

Aliphatic Index 97

Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 1490

Absorbance 280nm 165.56

Polar residues 4

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 14991605

Title The CD8+ T cell repertoire against Her-2/neu antigens in neu transgenic mice is of low avidity with antitumor activity

Doi 10.1002/eji.200324427

Year 2004

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available