This work is licensed under a Creative Commons Attribution 4.0 International License.
P. sajor-caju Rnase
General Information
DRACP ID DRACP00109
Peptide Name P. sajor-caju Rnase
Sequence DNGEAGRAAR
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Pleurotus sajor-caju
Type Native peptide
Classification
Active ACP Affect cell cycle
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| L1210 | Mouse leukemia | Leukemia | IC50=0.1 µM | MTT assay | 48h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | IC50=0.2 µM | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Mouse splenocytes: IC50=0.065 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C38H65N17O16
Absent amino acids CFHIKLMPQSTVWY
Common amino acids A
Mass 117676
Pl 6.49
Basic residues 2
Acidic residues 2
Hydrophobic residues 3
Net charge 0
Boman Index -4470
Hydrophobicity -149
Aliphatic Index 30
Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15003351
Title A ribonuclease with antimicrobial, antimitogenic and antiproliferative activities from the edible mushroom Pleurotus sajor-caju
Doi 10.1016/j.peptides.2003.11.012
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.