This work is licensed under a Creative Commons Attribution 4.0 International License.
HCAP18(109-135)
General Information
DRACP ID DRACP00110
Peptide Name HCAP18(109-135)
Sequence FRKSKEKIGKEFKRIVQRIKDFLRNLV
Sequence Length 27
PubChem CID Not available
Origin hCAP18 Synthetic
Type Synthetic peptide
Classification
Active ACP Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SAS-H1 | Tongue squamous cell carcinoma; Squamous cell carcinoma of the oral tongue | Carcinoma | 88 ± 7.2% cytotoxicity=40 mg/ml | Trypan blue assay | 24-96 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C155H263N47O37
Absent amino acids ACHMPTWY
Common amino acids K
Mass 384101
Pl 11.75
Basic residues 10
Acidic residues 3
Hydrophobic residues 10
Net charge 7
Boman Index -8834
Hydrophobicity -82.22
Aliphatic Index 93.7
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15279899
Title C-terminal domain of human CAP18 antimicrobial peptide induces apoptosis in oral squamous cell carcinoma SAS-H1 cells
Doi 10.1016/j.canlet.2004.04.006
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.