V4

General Information


DRACP ID  DRACP00115

Peptide Name   V4

Sequence  CVKVQVKVGSGVKVQVKVC

Sequence Length  19

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
THP-1 Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia Leukemia IC50=88 µM CellTiter 96 AQueous One Solution assay 1 h 1

Hemolytic Activity  Human erythrocytes: 50% Hemolysis=3226 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00115

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys1<--->Cys19

N-terminal Modification  Acetylization

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C87H159N25O23S2

Absent amino acids  ADEFHILMNPRTWY

Common amino acids  V

Mass  230875

Pl  10.35

Basic residues  4

Acidic residues  0

Hydrophobic residues  8

Net charge  4

Boman Index  8

Hydrophobicity  75.79

Aliphatic Index  122.11

Half Life 
  Mammalian: 1.2 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  125

Absorbance 280nm  6.94

Polar residues  5

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 15328096

Title  De novo design of potent antimicrobial peptides

Doi 10.1128/AAC.48.9.3349-3357.2004

Year  2004

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.