This work is licensed under a Creative Commons Attribution 4.0 International License.
V6
General Information
DRACP ID DRACP00117
Peptide Name V6
Sequence CFKFKFKFGSGFKFKFKFC
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | IC50=45 µM | CellTiter 96 AQueous One Solution assay | 1 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=35 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys1<--->Cys19
N-terminal Modification Acetylization
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C121H167N25O21S2
Absent amino acids ADEHILMNPQRTVWY
Common amino acids F
Mass 269315
Pl 10.8
Basic residues 6
Acidic residues 0
Hydrophobic residues 8
Net charge 6
Boman Index -842
Hydrophobicity 12.63
Aliphatic Index 0
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 6.94
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15328096
Title De novo design of potent antimicrobial peptides
Doi 10.1128/AAC.48.9.3349-3357.2004
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.