This work is licensed under a Creative Commons Attribution 4.0 International License.
TAT-Ras-GAP317-326
General Information
DRACP ID DRACP00120
Peptide Name TAT-Ras-GAP317-326
Sequence GRKKRRQRRRGGWMWVTNLRTD
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin RasGAP-derived peptides
Type Native peptide
Classification
Transducing peptide Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | rendered all the tested cancer cell lines sensitive to doses of cisplatin, adriamycin, and mitoxantrone | FITC fluorophore assay | 20 h | 1 |
| U2OS | Human osteosarcoma | Sarcoma | rendered all the tested cancer cell lines sensitive to doses of cisplatin, adriamycin, and mitoxantrone | FITC fluorophore assay | 20 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | rendered all the tested cancer cell lines sensitive to doses of cisplatin, adriamycin, and mitoxantrone | FITC fluorophore assay | 20 h | 1 |
| H-Meso-1 | Human malignant mesothelomia | Carcinoma | rendered all the tested cancer cell lines sensitive to doses of cisplatin, adriamycin, and mitoxantrone | FITC fluorophore assay | 20 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Enhances genotoxin-induced cytotoxicity in tumor cells
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C119H201N49O29S
Absent amino acids ACEFHIPSY
Common amino acids R
Mass 318901
Pl 12.9
Basic residues 9
Acidic residues 1
Hydrophobic residues 4
Net charge 8
Boman Index -12279
Hydrophobicity -201.36
Aliphatic Index 30.91
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 11000
Absorbance 280nm 523.81
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15467750
Title A RasGAP-derived cell permeable peptide potently enhances genotoxin-induced cytotoxicity in tumor cells
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.