This work is licensed under a Creative Commons Attribution 4.0 International License.
Coccinin
General Information
DRACP ID DRACP00121
Peptide Name Coccinin
Sequence KQTENLADTY
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Phaseolus coccineus
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50=30 µM | MTT assay | 72 h | 1 |
| L1210 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50=40 µM | MTT assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antifungal; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C50H79N13O20
Absent amino acids CFGHIMPRSVW
Common amino acids T
Mass 134297
Pl 4.18
Basic residues 1
Acidic residues 2
Hydrophobic residues 2
Net charge -1
Boman Index -3181
Hydrophobicity -150
Aliphatic Index 49
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 165.56
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15572193
Title Coccinin, an antifungal peptide with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from large scarlet runner beans
Doi 10.1016/j.peptides.2004.08.003
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.