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Apo E
General Information
DRACP ID DRACP00124
Peptide Name Apo E
Sequence LRVRLASHLRKLRKRLLRDADDLQKRLAVY
Sequence Length 30
UniProt ID Not available
PubChem CID Not available
Origin Apoprotein E
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| PANC-1 | Pancreatic ductal adenocarcinoma | Carcinoma | 55 % Cytotoxity at 40 µg/ml | MTT assay | 4 h | 1 |
| Mia PaCa-2 | Pancreatic ductal adenocarcinoma | Carcinoma | 55 % Cytotoxity at 40 µg/ml | MTT assay | 4 h | 1 |
| MKN1 | Gastric adenosquamous carcinoma | Carcinoma | 60 % Cytotoxity at 40 µg/ml | MTT assay | 4 h | 1 |
| MKN7 | Gastric tubular adenocarcinoma | Carcinoma | 35 % Cytotoxity at 40 µg/ml | MTT assay | 4 h | 1 |
| COLO 201 | Colon adenocarcinoma | Carcinoma | 65 % Cytotoxity at 40 µg/ml | MTT assay | 4 h | 1 |
Hemolytic Activity Human red blood cells: ApoE does not lyse erythrocytes
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism ApoE has anti-tumor activity, probably through perturbation and formation of ionpermeable "pores" in membranes
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C162H287N57O40
Absent amino acids CEFGIMNPTW
Common amino acids L
Mass 419089
Pl 12.14
Basic residues 11
Acidic residues 3
Hydrophobic residues 13
Net charge 8
Boman Index -10812
Hydrophobicity -61
Aliphatic Index 133.33
Half Life
Mammalian: 1 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 51.38
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15796184
Title Anti-tumor activity of an antibiotic peptide derived from apoprotein E
Doi Not available
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.