This work is licensed under a Creative Commons Attribution 4.0 International License.
hP7
General Information
DRACP ID DRACP00132
Peptide Name hP7
Sequence ETWRTEAPSATGQASSLLGGRLLGQ
Sequence Length 25
UniProt ID P39060
PubChem CID Not available
Origin Human endostatin peptides
Type Native peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| BxPC-3 | Pancreatic ductal adenocarcinoma | Carcinoma | No inhibition at 7 mg/kg/d | Matrigel Assay | 672 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target α5β1 integrin, metalloproteinases
Affinity Not available
Mechanism Inhibition of endothelial cell proliferation, migration, and tube formation
Nature Anticancer; Antiangiogenesis
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C110H180N34O38
Absent amino acids CDFHIKMNVY
Common amino acids GL
Mass 301511
Pl 6.53
Basic residues 2
Acidic residues 2
Hydrophobic residues 8
Net charge 0
Boman Index -4125
Hydrophobicity -44
Aliphatic Index 74.4
Half Life
Mammalian: 3.5 hour
Yeast: 10 min
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 229.17
Polar residues 10
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15867360
Title A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity
Doi 10.1158/0008-5472.CAN-04-1833
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.