This work is licensed under a Creative Commons Attribution 4.0 International License.
hP8
General Information
DRACP ID DRACP00133
Peptide Name hP8
Sequence LGQSAASAHHAYIVLAIENSFMTASKKK
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Human endostatin peptides
Type Native peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| BxPC-3 | Pancreatic ductal adenocarcinoma | Carcinoma | No inhibition at 7 mg/kg/d | Matrigel Assay | 672 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target α5β1 integrin, metalloproteinases
Affinity Not available
Mechanism Inhibition of endothelial cell proliferation, migration, and tube formation
Nature Anticancer; Antiangiogenesis
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C132H213N37O39S
Absent amino acids CDPRW
Common amino acids A
Mass 345622
Pl 10.12
Basic residues 5
Acidic residues 1
Hydrophobic residues 12
Net charge 4
Boman Index -2042
Hydrophobicity 7.5
Aliphatic Index 87.5
Half Life
Mammalian: 1 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 55.19
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15867360
Title A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity
Doi 10.1158/0008-5472.CAN-04-1833
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.