This work is licensed under a Creative Commons Attribution 4.0 International License.
Laxaphycin B
General Information
DRACP ID DRACP00134
Peptide Name Laxaphycin B
Sequence AXQNXXXPLXXVX
Sequence Length 13
UniProt ID Not available
PubChem CID 457000
Origin Terrestrial blue-green alga Anabaena laxa or the marine cyanobacterium Lyngbya Majuscula
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| CEM-WT | human lymphoblastic cancer | Lymphoma | 50% inhibition at 1 µM | Cell Viability assay | 96 h | 1 |
| CEM-WT | human lymphoblastic cancer | Lymphoma | 44% inhibition at 1 µM | Cell Viability assay | 96 h | 1 |
| CEM/VM-1 | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | 44% inhibition at 1 µM | Cell Viability assay | 96 h | 1 |
| CEM-VLB | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | 44% inhibition at 1 µM | Cell Viability assay | 96 h | 1 |
| CEM-WT | human lymphoblastic cancer | Lymphoma | 40% inhibition at 1 µM | Cell Viability assay | 96 h | 1 |
| CEM/VM-1 | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | 40% inhibition at 1 µM | Cell Viability assay | 96 h | 1 |
| CEM-VLB | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | 40% inhibition at 1 µM | Cell Viability assay | 96 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond X1<--->X13
N-terminal Modification None
C-terminal Modification None
Other Modification X(2/13)=Leu(3-OH); X(5)=N(Me)xiIle; X(6)=Asn(3-OH); X(7/10)=xiThr; X(11)=Unk
Chiral L
Physicochemical Information
Formula C28H34N8O2
Absent amino acids CDEFGHIKMRSTWY
Common amino acids X
Mass 149885
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index -141
Hydrophobicity 9.23
Aliphatic Index 60
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15875779
Title Cytotoxic effect of Laxaphycins A and B on human lymphoblastic cells (CCRF-CEM) using digitised videomicrofluorometry
Doi Not available
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.