This work is licensed under a Creative Commons Attribution 4.0 International License.
sesquin
General Information
DRACP ID DRACP00136
Peptide Name sesquin
Sequence KTCENLADTY
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Ground beans
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| M1 | Mouse myeloid leukemia | Leukemia | Inhibition of viability about 85% | MTT assay | 24 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | Inhibition of viability about 75% | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C48H76N12O19S
Absent amino acids FGHIMPQRSVW
Common amino acids T
Mass 131798
Pl 4.18
Basic residues 1
Acidic residues 2
Hydrophobic residues 2
Net charge -1
Boman Index -2499
Hydrophobicity -90
Aliphatic Index 49
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 1490
Absorbance 280nm 165.56
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15949629
Title Sesquin, a potent defensin-like antimicrobial peptide from ground beans with inhibitory activities toward tumor cells and HIV-1 reverse transcriptase
Doi 10.1016/j.peptides.2005.01.003
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.