Pep27anal3

General Information


DRACP ID  DRACP00139

Peptide Name   Pep27anal3

Sequence  MRKWFHNVLSSGQLLADKWPAWDYNRK

Sequence Length  27

UniProt ID  Not available

PubChem CID  Not available

Origin  S. pneumoniae

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
OCI-AML-2 Adult acute myeloid leukemia; Acute myeloid leukemia Leukemia IC50=67 µM MTT assay 20.08 min 1
HL-60 Adult acute myeloid leukemia; Acute myeloid leukemia Leukemia IC50=52 µM MTT assay 20.08 min 1
Jurkat Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia Leukemia IC50=50 µM MTT assay 20.08 min 1
SNU-601 Gastric signet ring cell adenocarcinoma Carcinoma IC50=50 µM MTT assay 20.08 min 1
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=38 µM MTT assay 20.08 min 1

Hemolytic Activity  Human RBCs(0% hemolysis at 0.19 μM, 0.39 μM, 0.78 μM, 1.56 μM, 3.12 μM, 6.25 μM, 12.5 μM)

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00139

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C155H228N44O38S

Absent amino acids  CEIT

Common amino acids  KLW

Mass  381179

Pl  10.63

Basic residues  6

Acidic residues  2

Hydrophobic residues  10

Net charge  4

Boman Index  -5867

Hydrophobicity  -92.96

Aliphatic Index  61.48

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  17990

Absorbance 280nm  691.92

Polar residues  6

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 16004618

Title  Functional and structural characteristics of anticancer peptide Pep27 analogues

Doi 10.1186/1475-2867-5-21

Year  2005

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.