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Pep27anal5
General Information
DRACP ID DRACP00141
Peptide Name Pep27anal5
Sequence MWKWFHNVLSSGQLLADKWWAWWYNWW
Sequence Length 27
UniProt ID Not available
PubChem CID Not available
Origin S. pneumoniae
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| OCI-AML-2 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50>70 µM | MTT assay | 19.17 min | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50>70 µM | MTT assay | 19.17 min | 1 |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50>70 µM | MTT assay | 19.17 min | 1 |
| SNU-601 | Gastric signet ring cell adenocarcinoma | Carcinoma | IC50>70 µM | MTT assay | 19.17 min | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50>70 µM | MTT assay | 19.17 min | 1 |
Hemolytic Activity Human RBCs(0% hemolysis at 0.19 μM, 0.39 μM, 0.78 μM, 1.56 μM, 3.12 μM, 6.25 μM, 12.5 μM)
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C183H230N42O36S
Absent amino acids CEIPRT
Common amino acids W
Mass 409011
Pl 9.26
Basic residues 3
Acidic residues 1
Hydrophobic residues 15
Net charge 2
Boman Index -291
Hydrophobicity -42.96
Aliphatic Index 61.48
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 45490
Absorbance 280nm 1749.62
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16004618
Title Functional and structural characteristics of anticancer peptide Pep27 analogues
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.