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Pep27
General Information
DRACP ID DRACP00142
Peptide Name Pep27
Sequence MRKEFHNVLSSGQLLADKRPARDYNRK
Sequence Length 27
UniProt ID Not available
PubChem CID Not available
Origin S. pneumoniae
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| OCI-AML-2 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | Not available | MTT assay | 14.54 min | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | IC50>70 µM | MTT assay | 14.54 min | 1 |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50>70 µM | MTT assay | 14.54 min | 1 |
| SNU-601 | Gastric signet ring cell adenocarcinoma | Carcinoma | IC50>70 µM | MTT assay | 14.54 min | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50>70 µM | MTT assay | 14.54 min | 1 |
Hemolytic Activity Human RBCs(0% hemolysis at 0.19 μM, 0.39 μM, 0.78 μM, 1.56 μM, 3.12 μM, 6.25 μM, 12.5 μM)
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C139H229N47O40S
Absent amino acids CITW
Common amino acids R
Mass 369463
Pl 11.07
Basic residues 8
Acidic residues 3
Hydrophobic residues 7
Net charge 5
Boman Index -10231
Hydrophobicity -129.26
Aliphatic Index 61.48
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 57.31
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16004618
Title Functional and structural characteristics of anticancer peptide Pep27 analogues
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.