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Tyroserleutide
General Information
DRACP ID DRACP00145
Peptide Name Tyroserleutide
Sequence YSL
Sequence Length 3
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| B16-F10 | Mouse melanoma | Carcinoma | 61.2% cytotoxic at 100 µg/ml | MTT assay | 96 h | 1 |
| BEL-7402 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 39.0% cytotoxic at 0.1 µg/ml | MTT assay | 96 h | 1 |
| BEL-7402 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 20.8% cytotoxic at 1 µg/ml | MTT assay | 96 h | 1 |
| BEL-7402 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 33.8% cytotoxic at 10 µg/ml | MTT assay | 96 h | 1 |
| BEL-7402 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 35.6% cytotoxic at 100 µg/ml | MTT assay | 96 h | 1 |
| B16-F10 | Mouse melanoma | Carcinoma | 49.4% cytotoxic at 0.1 µg/ml | MTT assay | 96 h | 1 |
| B16-F10 | Mouse melanoma | Carcinoma | 51.2% cytotoxic at 1 µg/ml | MTT assay | 96 h | 1 |
| B16-F10 | Mouse melanoma | Carcinoma | 53.0% cytotoxic at 10 µg/ml | MTT assay | 96 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Enhances the antitumor effects of macrophages and stimulates macrophage secretion of IL-1β, TNF-α, and NO in vitro
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C18H27N3O6
Absent amino acids ACDEFGHIKMNPQRTVW
Common amino acids LSY
Mass 41728
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 1
Net charge 0
Boman Index 138
Hydrophobicity 56.67
Aliphatic Index 130
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 1490
Absorbance 280nm 745
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16091933
Title Tripeptide tyroserleutide enhances the antitumor effects of macrophages and stimulates macrophage secretion of IL-1beta, TNF-alpha, and NO in vitro
Doi 10.1007/s00262-005-0024-10
Year 2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.