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r8-BadBH3
General Information
DRACP ID DRACP00150
Peptide Name r8-BadBH3
Sequence rrrrrrrrGNLWAAQRYGRELRRMSDEFVDSFKK
Sequence Length 34
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SK-N-AS | Neuroblastoma; Neuroblastoma | Blastoma | 0% apoptosis at 10 µM | MTT assay | 8 h | 1 |
| SK-N-AS | Neuroblastoma; Neuroblastoma | Blastoma | 10% apoptosis at 20 µM | MTT assay | 8 h | 1 |
| SK-N-AS | Neuroblastoma; Neuroblastoma | Blastoma | 30% apoptosis at 50 µM | MTT assay | 8 h | 1 |
| NB69 | Neuroblastoma | Blastoma | 30% apoptosis at 10 µM | MTT assay | 8 h | 1 |
| NB69 | Neuroblastoma | Blastoma | 80% apoptosis at 20 µM | MTT assay | 8 h | 1 |
| NB69 | Neuroblastoma | Blastoma | 80% apoptosis at 50 µM | MTT assay | 8 h | 1 |
| NGP | NeuroblastomaDerived from metastatic site: Lung. | Blastoma | 20% apoptosis at 10 µM | MTT assay | 8 h | 1 |
| NGP | NeuroblastomaDerived from metastatic site: Lung. | Blastoma | >50% apoptosis at 20 µM | MTT assay | 8 h | 1 |
| NGP | NeuroblastomaDerived from metastatic site: Lung. | Blastoma | 30% apoptosis at 50 µM | MTT assay | 8 h | 1 |
| IMR-5 | Neuroblastoma | Blastoma | 15% apoptosis at 10 µM | MTT assay | 8 h | 1 |
| IMR-5 | Neuroblastoma | Blastoma | 20% apoptosis at 20 µM | MTT assay | 8 h | 1 |
| IMR-5 | Neuroblastoma | Blastoma | 50% apoptosis at 50 µM | MTT assay | 8 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Induce apoptosis in highly malignant NB-derived cell lines
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification rrrrrrrr=D-isomer homopolymer of eight arginine residues
Chiral Mix
Physicochemical Information
Formula C139H199N43O32S
Absent amino acids CHIPT
Common amino acids R
Mass 360521
Pl 10.23
Basic residues 6
Acidic residues 4
Hydrophobic residues 8
Net charge 2
Boman Index -9094
Hydrophobicity -83.82
Aliphatic Index 37.35
Half Life
/
Extinction Coefficient cystines 6990
Absorbance 280nm 211.82
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16568093
Title BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma
Year 2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.