This work is licensed under a Creative Commons Attribution 4.0 International License.
r8-BidBH3
General Information
DRACP ID DRACP00151
Peptide Name r8-BidBH3
Sequence rrrrrrrrGEDIIRNIARHLAQVGDSMDR
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SK-N-AS | Neuroblastoma; Neuroblastoma | Blastoma | 8% apoptosis at 10 µM | MTT assay | 8 h | 1 |
| SK-N-AS | Neuroblastoma; Neuroblastoma | Blastoma | 45% apoptosis at 20 µM | MTT assay | 8 h | 1 |
| SK-N-AS | Neuroblastoma; Neuroblastoma | Blastoma | 65% apoptosis at 50 µM | MTT assay | 8 h | 1 |
| NB69 | Neuroblastoma | Blastoma | 25% apoptosis at 10 µM | MTT assay | 8 h | 1 |
| NB69 | Neuroblastoma | Blastoma | 66% apoptosis at 20 µM | MTT assay | 8 h | 1 |
| NB69 | Neuroblastoma | Blastoma | 68% apoptosis at 50 µM | MTT assay | 8 h | 1 |
| NGP | NeuroblastomaDerived from metastatic site: Lung. | Blastoma | 43% apoptosis at 10 µM | MTT assay | 8 h | 1 |
| NGP | NeuroblastomaDerived from metastatic site: Lung. | Blastoma | 46% apoptosis at 20 µM | MTT assay | 8 h | 1 |
| NGP | NeuroblastomaDerived from metastatic site: Lung. | Blastoma | 79% apoptosis at 50 µM | MTT assay | 8 h | 1 |
| IMR-5 | Neuroblastoma | Blastoma | 23% apoptosis at 10 µM | MTT assay | 8 h | 1 |
| IMR-5 | Neuroblastoma | Blastoma | 35% apoptosis at 20 µM | MTT assay | 8 h | 1 |
| IMR-5 | Neuroblastoma | Blastoma | 55% apoptosis at 50 µM | MTT assay | 8 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Induce apoptosis in highly malignant NB-derived cell lines
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification rrrrrrrr=D-isomer homopolymer of eight arginine residues
Chiral Mix
Physicochemical Information
Formula C97H148N34O25S
Absent amino acids CFKPTWY
Common amino acids DIR
Mass 272214
Pl 5.57
Basic residues 4
Acidic residues 4
Hydrophobic residues 7
Net charge 0
Boman Index -6640
Hydrophobicity -42.41
Aliphatic Index 70.69
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 16568093
Title BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma
Year 2006
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.